Both WordPress.com and WordPress.org have their advantages and disadvantages.
The best between the two will depend on your needs or expectations, the type of website you are launching, and your budget.
For instance, if you are running a personal blog, hobby website, or un-monetized site, you should choose WordPress.com. You can also use it if you are looking to start a personal project to test or share your thoughts or hobbies.
This option will enable you to set up and launch your website quickly without spending a lot of money.
Given that WordPress will provide maintenance and support, you will be good to go either on a free or paid personal plan.
However, if you would like to launch a professional site or site for business, projects, and eCommerce, you should go for WordPress.org. This platform will enable you to monetize your site and customize it as desired.
Given the issues discussed, WordPress.com wins in the following areas:
Setup, installation, and ease of use
Backup and security
In contrast, WordPress.org scores better in the following areas:
Theme design and customization
Both WordPress.com and WordPress.org score fairly well. The best choice will depend on the factors addressed earlier, though you can always migrate from WordPress.com to WordPress.org as your needs change.